I've been in a microphones-centric Discord server for a while picking up a few things and it seems MOTU interfaces are known to develop odd problems over time, though not to the same extent as the entry level Focusrite Scarletts.
Previously, the hub was not in use. That's when problem first showed. It was connected to USB-C on PC. Tomorrow I will get a cable C to A to try other onboard ports
@crenca "maybe the hub is not giving it enough amps"
I think that power supply might be part of the problem (in which case, the PC port which was powering it fine for a couple of years must have changed). I also think that one of my plugins might be.
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