First up, pardon if this is the wrong subforum to post it. At first I was going to post it as a reply to my post in the all purpose advice thread since I don't think too many people will care about this comparison, but maybe some will find it interesting. I was initially going to post this much earlier, but I still think it's relevant today, so I'm still going to post it. An old TerraTec DMX6Fire USB interface that my dad didn't need anymore started giving up the ghost recently, so I looked for a replacement. I used to use it for some rough vinyl rips and as a mic preamp with phantom power for gaming. In the price range that I was looking at I only found the Steinberg UR22C, Focusrite Scarlett 2i2 Gen 3 and finally the MOTU M4. Another option would be to buy a used Clarett range Focusrite, which also seems like a viable option. I compared the sound as an ADC unless otherwise noted. Made vinyl rips and compared them across three different systems. Steinberg UR22C AD/DA: Forgot, will update asap Sounded the warmest, still - tonality is just slightly warm Most lacking in plankton The stage also seemed the smallest Transients somewhat rounded, everything just sounds smoothed over Slight grain aswell Overall I thought this one was clearly the worst Still, the input mix volume button and being able to use the 5V power switch as an on/off switch when not connected to an external 5V PSU were features that I felt the 2i2G3 needed. Focusrite Scarlett 2i2 Gen 3 AD/DA: CS4272 (seemingly) Lean tonality, lacking in bass weight and treble is a bit too bright Less grainy than the UR22C though, overall a more liquid presentation The tonality is overall too lean for me to be enjoyable without EQ - I'd have to EQ the recordings. Despite this, no measured difference in FR. Spectrum looked virtually identical for the vinyl rips aswell. Stage is a bit wider and just slightly deeper. Overall a bit more competent in the technicalities: Definitely more resolving and better clarity. Still lacks macrodynamics Overall it seemed slightly better in the technicalities than the TerraTec that it replaced, but the tonality is worse The TerraTec sounds similar, but slightly warmer. Also seemed mostly grain-free. MOTU M4 After I was dissatisfied with the two other USB interfaces I also bought a Motu M4. I bought the M4 for its input monitor mix knob, which I thought was a fantastic feature the UR22C has. I liked being able to hear exactly what the other person hears through my microphone and being able to adjust my volume so it sounds natural. Like many people I don't usually like hearing my own voice, but I really like this feature. I couldn't find which ADC it used, so I opened mine. AKM AK5554VN ADC! Perfect! Dedicated power button. I don't get why so many other interfaces lack such a basic feature. Inevitably they will stay on and die much earlier due to component failure. My TerraTec probably wouldn't be dead now if it had a proper power button. This one has a very different presentation to the other two that is hard to explain. Right off the bat it sounds warmer than the 2i2 Gen 3, but also not as warm as the UR22C. Closer to the UR22C, though and if anything leaning slightly warm. I'm still unsure about it, but I think it's a bit grainy. Nothing dealbreaking and overall it sounds more like the 2i2G3 sounds overly smooth at times despite its bright tonality. Overall it just seems to sound more colorful in the way it presents different sounds. That's the part that is hard to explain for me, but it just seems to leave more of the instrument's sounds intact. Seems to have a broader palette of timbres and sounds if that makes any sense. I think it plays a role in the above, but it also just sounded a bit more vivid in general. Microdynamics seemed less compressed. I think it also resolves a bit more low level information than the 2i2G3, though not as much as you'd expect given the otherwise very favorable impressions. A lot of it is still missing. Bass extension is also slightly lacking. UR22C seems to go the deepest subjectively. 2i2 is similar. The inputs seem to clip 1dB quieter than the specs indicate according to my measurements. Either way, a normal XLR DAC output will clip the inputs at the minimum gain. Will need to use attentuators. I wish it wasn't that way. So this is the one I ended up keeping. Despite being slightly more expensive than I initially would've liked to spend, it was the only one I thought was a decent upgrade over my TerraTec thingy. One thing that put me off was that it uses a SABRE DAC, so I'd have to listen to SABRE during gaming. I found that this was one of the warmer SABRE implementations, though. It seems like they really tried to smooth over the sandpaper treble of the typical SABRE DACs. I even found the sound out of the headphone output to be slightly better than the other two interfaces: Slightly larger stage, more resolving of low level information, better clarity. It's not as good as a GO2A (even from its SE output), but I found it usable and definitely more than good enough for gaming. The 2i2 and UR22C sounded very similar when used as an ADC and as a DAC, not so the M4, though. M4 sounds decidedly smoother and more natural as an ADC compared to its DAC section. I'd recommend it more as a ADC than using it as a real audio interface for driving powered monitors, for example. But even in that case it does the job. Also the small LCD panel is immensely useful for getting the correct volume. It's helped me on multiple occasions to set the gain for my mic. Helps to see just how compressed modern music is, too. It even has 64dB of gain as compared to the 56dB of the 2i2G3. Doesn't help much with my fairly sensitive condenser mic, but using an inefficient dynamic mic it's probably a very good thing. I also seemed to get slightly less noise from the mic output when testing the limits of my mics (when digitally compensating for the gain difference). But getting the noise level indoors low enough to properly test it is virtually impossible.