I've had the Lyr 3 for a couple weeks now, and I am pretty happy with it. To preface, I'm using them to feed a pair of HD600 with rear foam removed, Damplifier Pro added, and Dekoni fenestrated sheepskin pads. Source is Eitr -> Modi Multibit -> Loki (2:30, 1 o'clock, 11 o'clock, 11 o'clock). I'm still figuring out exactly what my tastes are and how to describe them, but I would say that I like transparency and clarity, but I am also somewhat treble sensitive and prefer a strong low end. Listening was with the Tung-Sol tube on high gain, with the volume at about 9 o'clock. Before the Lyr 3, I was using an MCTH with the stock tube. I'm pretty skeptical of my own ear and was actually expecting to have to A/B to perceive any difference between the two, but was pleasantly surprised to find that the difference was actually pretty apparent. I noticed better instrument separation, bass quantity, extension, and definition, as well as improved clarity off the bat. I also think that dynamics and detail are a bit better with the Lyr, and that the treble is less prominent. I think that the reduced treble is good for me, as I found myself getting fatigued more easily with the MCTH. I do, however, feel that the soundstage has less depth than the MCTH. I still prefer the spatial presentation of the Lyr, however, because of the better instrument separation and air. Bass is also still a bit less than I'd like, but I think that's probably more a product of the headphone than the amp. I actually got the Lyr 3 along with the LCD 2C, expecting that the LCD 2C would replace the HD600 as my main headphone. I probably just have HD600-ear, but I felt like information was missing with the LCD 2C compared to the HD600, especially in the upper mids. The main reason I was looking at the LCD 2C was because I was getting fatigued frequently with HD600 + MCTH, but the Lyr 3 seems to have largely ameliorated this. I what second @Vtory said about the Lyr 3 having very good synergy with HD600 + Dekoni fenestrated sheepskin pads.